Diabeticnephropathymechanism

Another possible mechanism is that abnormal vascular control in diabetic nephropathy leads to a reduction in afferent glomerular arteriolar resistance and ...

由 N Samsu 著作 · 2021 · 被引用 512 次 — Increased ROS due to hyperglycemia is central to the pathogenesis of DN. In diabetes, the main sources of ROS include the polyol chain, AGE, and ...

由 S Giunti 著作 · 2006 · 被引用 219 次 — Clinical hallmarks of diabetic nephropathy include a progressive increase in urinary albumin excretion and a decline in glomerular filtration ...

2022年6月30日 — Hyperglycaemia leads to hyperfiltration, which is followed by metabolic, hormonal, haemodynamic, inflammatory and epigenetic changes. Oxidative ...

Pathophysiology is complex, involving glycosylation of proteins, hormonally influenced cytokine release (eg, transforming growth factor-beta), deposition of ...

由 J Rico-Fontalvo 著作 · 2022 · 被引用 37 次 — Diabetes mellitus leads to both hemodynamic factors, which include increased blood pressure and intraglomerular pressure, and metabolic factors ...

由 R Agarwal 著作 · 2021 · 被引用 21 次 — Diabetic nephropathy is classified histologically by the appearance of the glomerulus on kidney biopsy. It progresses from GBM thickening, to mesangial ...

由 CC Khoury 著作 · 2015 · 被引用 18 次 — Metabolic Mechanisms of Diabetic Nephropathy. Hyperglycemia acts as the main driver for the development and progression of DN. As mentioned above, glycemic ...